|Appears||Half-Lives: The First Luisa Rey Mystery|
|Previous Life||Tadeusz Kesselring|
|Next Life||Nurse Noakes|
Bill Smoke is the hired "fixer" (assassin), who reports to Alberto Grimaldi, the head of Seaboard Corporation, and ultimately Lloyd Hooks. It is Smoke who kills Rufus Sixsmith and makes it look like a suicide and who attempts to kill Luisa Rey. In the second portion of the "Luisa Rey" story, Smoke relentlessly pursues those who are planning to expose the HYDRA project, killing Fay Li and Joe Napier in the process. Smoke is killed by Joe Napier in the shoot-out that also kills Napier.
- "Bet you didn't learn that in the army."
- —Luisa Rey